Overweight and obesity are chronic diseases that have a profoundly negative impact on health worldwide. Over 80 million adults in the U.S. are obese, leading to 325,000 premature deaths and medical costs of 190 billion dollars per year. The U.S. Surgeon General has declared that the “epidemic of overweight and obesity threatens the historic progress we have made in increasing American’s quality and years of healthy life”. As obesity is associated with serious complications such as Nonalcoholic steatohepatitis (NASH), and type 2 diabetes (T2D), developing safe and effective anti-obesity treatments is a global priority.